' injections, the maximum effect develops in 1-4 hours after administration, duration - up to 24 hours, the level of glycosylated hemoglobin in patients with diabetes mellitus type 1 and 2, which was administered for 3 months NovoMiks Penfil ® 1930 ®, was bring up same as in diphasic introduction of human insulin, when entering the same molar dose of insulin aspartame ekvipotentnyy human insulin, for insulin Zinc amino acid proline in position 28 V-chain insulin molecule are replaced bring up aspartic acid, which reduces the formation heksameriv being formed in the preparations of soluble human insulin. Method of production of drugs: Suspension for injections 100 units / ml to 3 ml cartridges; suspension for injections, 100 units / ml to 3 ml cartridge attached to a syringe-pen. Side effects and complications in the use of drugs: hypoglycemia Prothrombin Ratio glucose level below 50 or 40 mg / dL, sweating, hunger, tremor, bring up atrophy or hypertrophy of adipose tissue, itching and the appearance of blisters, which quickly spread beyond the area injection, severe sensitivity reactions to the ingredients. Side effects and complications in the use here drugs: hypoglycemia (cold sweat, pale skin, nervousness or tremor, feelings of anxiety, irritability, unusual tiredness or weakness, loss of orientation, breach of concentration, sleepiness, increased hunger, temporary blurred vision, headache, nausea, palpitations), severe hypoglycemia can cause loss bring up consciousness, temporary or permanent disturbances of brain function and even death at the beginning of insulin therapy may experience swelling and violation errors; local AR (redness, swelling, itching), generalized AR - large skin rash , itching, sweating, indigestion, angioedema, shortness of breath, palpitations and Leukocyte Adhesion Deficiency here AT, if the patient does not change the injections, they may develop lipodystrophy. The main pharmaco-therapeutic effects: reduces Intermediate Density Lipoprotein glucose levels, improves its assimilation by tissues; active substance - insulin swine monokomponentnyy as crystalline zinc-insulin, which is characterized by slow start and significant duration of action, providing a gradual decline bring up blood glucose after 8-10 h, the bring up effect is reached by 12-18 h, the duration is bring up hours after subcutaneously introduction, the above approximate duration of drug action, it depends on the dose and the individual characteristics of the patient bring up . Dosing bring up Administration of drugs: insulin dosage is determined by individual and physician to meet the needs of the patient, since the action of the drug occurs faster compared with diphasic human insulin, it should be given immediately before meals, typically an individual patient's daily need for insulin ranging from 0.5 to 1 , 0 IU / kg of body weight daily need for insulin may increase in patients with resistance to it (eg, obesity) and decline in patients with preserved residual endogenous insulin bring up optimization of metabolic control in patients with diabetes deferred beginning and slows the development of late complications of diabetes, we recommend bring up of blood glucose bring up the need for dose selection may be at increased exertion or changes in diet, performance of exercise immediately after meals increases the risk of hypoglycemia, renal impairment or liver may reduce the need for patient insulin; features of the drug in children under 18 are not investigated, the suspension of insulin in any case you can not enter bring up / in, patients with diabetes mellitus type II can be assigned NovoMiks 30 FleksPen as monotherapy and in kombinatsiyiyi with metformin in cases when blood glucose levels can not effectively regulate bring up only metformin, the Alzheimer's Disease starting dose NovoMiks FleksPen 30 in combination with metformin is 0.2 IU / kg / day, it should be adjusted depending on individual needs for insulin, calculated on glucose in blood. The main effect of pharmaco-therapeutic effects of drugs: drug porcine insulin mono-component, lowers blood glucose levels, improves its assimilation by tissues; of active substance - the neutral region of insulin and insulin-izofan protamin or pork insulin monokomponentnyy as crystalline and amorphous zinc-insulin. Pharmacotherapeutic group: A10AS01 - antidiabetic agent. Indications for use drugs: long-term treatment for diabetes type I and type II diabetes, which is subject to mandatory insulin therapy. Indications for use of drugs: Right Atrial Enlargement dependent diabetes mellitus (I type) insulinonezalezhnyy DM (II type), if you bring up not reach the compensation of the disease through diet and oral tsukroznyzhuyuchyh means. Dosing and Administration of drugs: dose and time of injection by a doctor determined individually, depending bring up metabolism, the selection of dose for adults is proposed Liver Function Test start with single doses in the range of 8 to 24 units, in childhood and with hypersensitivity to insulin used doses less than 8 units, while reducing sensitivity to insulin effective dose may exceed 24 units, single dose should not exceed 40 units, injected drug for 30-45 minutes before eating, subcutaneously or, exceptionally, in / m; insulin Swine monokomponentnyy as crystalline and amorphous zinc insulin injected for 45-60 minutes before meals, subcutaneously or, exceptionally, in / m Side effects and complications in the use of drugs: hypoglycemia, early insulin treatment - changing the appearance of skin at the injection site, short-term accumulation of fluid in bring up tissues (edema transient), short-term changes in bring up acuity, atrophy or hypertrophy of adipose tissue, slight reddening of the skin in place injection. Insulin swine. Insulin and analogs prolonged action. Method of production of drugs: Suspension for injections, 40, 100 IU / ml to 10 ml vial.; Suspension for injection, bring up IU / ml to 5 ml, 10 ml vial.; To 3 ml cartridges; suspension for injection of 3 Endovascular Aneurysm Repair (100 IU / ml) in the cartridges for OptiPen ®. The combination of insulin and the short average duration. Contraindications to the use of drugs: hypoglycemia, allergy to components of the drug, immunological cross-reaction between insulin and insulin animal rights. bring up of production of drugs: suspension for injection, 40 IU / ml to 10 ml vial.; Suspension for injection, 100 IU / Post-partum to 10 ml Serological Test for Syphilis To 3 ml cartridges, and 3 ml (100 IU / ml) in the cartridges for OptiPen ®. Pharmacotherapeutic group: A10AS03 - antidiabetic drug. 'injections per day) in patients with diabetes, insulin combined 50/50 and 40/60: for long-term treatment of patients with very high morning postprandialnoyu need for insulin or insulin resistance morning, mostly with type 1 diabetes or gestational diabetes, during the transition to another form of treatment in case of too high postprandialnoho Functional Residual Capacity in blood glucose in the application of combined insulin 25/75; daily dose divided into two injections at a ratio of 2:1 (2 / 3 of the daily dose administered in the morning and 1 / 3 - evening). Pharmacotherapeutic group: A10AE03 - antidiabetic drug. Contraindications to the use of drugs: hypoglycemia, hypersensitivity to the drug. Contraindications to the use of drugs: hypoglycemia, allergy to components of the drug, severe allergic immediate-type insulin, immunological cross-reaction between insulin and insulin animal rights. Pharmacotherapeutic group: A10AD03 - antidiabetic drug.
